Description
Carprofen is a member of 2- arylpropionic acid group of non- steroidal anti- inflammatory drugs (NSAIDS), possesses anti-inflammatory, analgesic and antipyretic activity. Carprofen is a chiral drug. Carperofen, like most other NSAIDs is an inhibitor of the enzyume cycloxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of carprofen is not clear.
Carprofen is rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally. Peak blood plasma concentrations are achieved in 1-3 hours after oral administration of 1,5, and 25mg/kg to dogs. The mean terminal half- life of carprofen is approximately 8 hours ( range 4.5-9.8 hours ). Carprofen has a small volume of distribution and a low systemic clearance. It highly bound to plasma protein.
 
 Indications:
Carpropain is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
 
Dosage and Administration:
For oral administration. Carpropain can be given by mouth or placed on food. The recommended initial dose of carprofen is 1 to 2mg/lb (2.2 to 4.4mg/kg) body weight /day, divided in 2 equal doses. Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular Veterinary supervision.